Jwh021 new

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JWH-018 (1-pentyl-3-(1-naphthoyl)indoleNA-PIMO or AM-678)  is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as “incense blends”.

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JWH-018 We provide a number of variations of the herbal concoction referred to as “Spice.” This synthetic cannabinoid is usually used illegally due to its intoxicating properties, which are comparable to those of 9-THC in cannabis. Despite being much more effective than comparable cannabis dosages, JWH 021 is also very difficult to identify using standard 9-THC testing techniques. JWH-021 was added to the US Drug Enforcement Agency’s (DEA) list of substances and substances of concern in July 2009. Other states, such as Alabama, Arkansas, and Florida, have enacted laws limiting the sale or possession of JWH021 powder in addition to reports of Spice seizures in Ohio and Florida.

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WIN 55,212-2 is the source of JWH 021, an aminoalkylindole that functions as a CB2 receptor agonist with a slight degree of selectivity. For a CB1:CB2 ratio of 3.061, the Ki values for binding to the CB1 and CB2 receptors are 9.0 and 2.94 nM, respectively. The results of the tests on rats were similar to those of WIN 55,212-2 in terms of inhibition of spontaneous activity, maximum antinociceptive impact in the tail-flick experiment, and rectal temperature. Sales of JWH 021 powder online in the US

JWH 021 accessible in the United States

Animal pharmacology studies indicate that the JWH 021 pill functions similarly to 9-THC. It causes catalepsy, analgesia, a fall in body temperature, and a general decrease in activity in mice. Researchers are able to predict psychoactivity in Individuals who combine all four of these effects are similar to individuals who utilize 9-THC. Based on its results in all four tests, JWH 021 is likely to produce psychoactive effects in humans that are similar to those of THC. JWH 021 generated subjective responses that were comparable to 9-THC in rat trials on drug discrimination, and these responses extended to 9-THC. JWH 021 may work similarly to 9-THC in vivo since it binds to the brain cannabinoid receptor CB1 more strongly than 9-THC and exhibits agonist properties in functional testing. LegitGrams

 

 

 

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