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JWH-018, We provide several iterations of the herbal mixture known as “Spice.” Because of the intoxicating qualities of this synthetic cannabinoid, which are similar to those of cannabis’ 9-THC, it is mostly used illegally. While JWH 021 is significantly more potent than similar cannabis dosages, it also presents significant challenges for identification with conventional 9-THC testing methods. In July 2009, JWH-021 was added to the list of drugs and chemicals of concern maintained by the US Drug Enforcement Agency (DEA). In addition to reports of seizures of Spice in Ohio and Florida, other states, including Alabama, Arkansas, and Florida, have passed legislation restricting the sale or possession of JWH021 powder.

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JWH 021, an aminoalkylindole derived from WIN 55,212-2, is a CB2 receptor agonist that exhibits a minor degree of selectivity. The Ki values for binding to the CB1 and CB2 receptors, respectively, are 9.0 and 2.94 nM for a CB1:CB2 ratio of 3.061. Rats were tested, and the results were comparable to those of WIN 55,212-2 in terms of rectal temperature, maximum antinociceptive impact in the tail-flick assay, and inhibition of spontaneous activity. Online JWH 021 powder sales in the United States

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According to animal pharmacology research, JWH 021 tablet acts similarly to 9-THC. In mice, it results in analgesia, a drop in body temperature, catalepsy, and an overall decrease in activity. Researchers are able to predict psychoactivity in People who use all four of these effects together are comparable to those who use 9-THC. JWH 021’s performance in all four tests suggests that it will probably have psychoactive effects akin to those of THC in people. In studies on drug discrimination in rats, JWH 021 produced subjective responses similar to those of 9-THC, which generalized to 9-THC. JWH 021 binds to the brain cannabinoid receptor CB1 with more affinity than 9-THC and demonstrates agonist characteristics in functional tests, suggesting that it might function similarly to 9-THC in vivo. LegitGrams