MFPEP

The research medication 2-Methyl-6-(phenylethynyl)pyridine (MPEP) was among the first substances to be discovered to function as a selective antagonist for the mGluR5 subtype of the metabotropic glutamate receptor.

MPEP has primarily been used as a lead compound to create more powerful and selective mGluR5 antagonists like MTEP. However, studies employing MPEP itself are still ongoing, and it was recently demonstrated to decrease the amount of nicotine, cocaine, ketamine, and heroin that animals self-administer, possibly by amplifying the rewarding effect of the drug that is self-administered. Additionally, MPEP was found to have weak reinforcing effects on its own.

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