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A semi-synthetic opioid alkaloid with analgesic properties, oxycodone resembles morphine. By attaching to mu receptors in the central nervous system (CNS), oxycodone mimics the effects of endogenous opioids and produces an analgesic effect. When the opiate receptor is bound, the G-protein complex exchanges GTP for PDB and adenylate cyclase is inhibited, which stops the synthesis of cAMP. Moreover, substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and norepinephrine are among the nociceptive neurotransmitters whose release is suppressed. LegitGrams

Moreover, oxycodone prevents the secretion of glucagon, insulin, somatostatin, and vasopressin. Furthermore, oxycodone causes internal potassium channel repair by closing voltage-gated N-type calcium channels and opening G protein-bound potassium channels. This causes hyperpolarization and a reduction in neuronal excitability.

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