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Like morphine, oxycodone is a semi-synthetic opioid alkaloid that has analgesic effects. Oxycodone mimics the effects of endogenous opioids and creates an analgesic effect by binding to mu receptors in the central nervous system (CNS). The generation of cAMP is halted when the opiate receptor is engaged because the G-protein complex converts GTP to PDB and inhibits adenylate cyclase. Moreover, the release of nociceptive neurotransmitters is inhibited, including substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and norepinephrine. LegitGrams

Moreover, oxycodone prevents the secretion of glucagon, insulin, somatostatin, and vasopressin. Furthermore, oxycodone causes internal potassium channel repair by closing voltage-gated N-type calcium channels and opening G protein-bound potassium channels. This causes hyperpolarization and a reduction in neuronal excitability.

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