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JWH 018, a relatively selective agonist of the human peripheral cannabinoid (CB2) receptor, is made from the aminoalkylindole WIN 55,212-2. The Ki values for binding to the CB1 and CB2 receptors are 9.0 and 2.94 nM, respectively, yielding a CB1:CB2 ratio of 3.061. Rats were used in the tests, and the results showed that WIN 55,212-2 was comparable in terms of inhibition of spontaneous activity, maximum antinociceptive impact in the tail-flick assay, and rectal temperature.Online sales of JWH 018 powder in the US

JWH-018 is available in the United States.

According to research on animal pharmacology, 018 tablets work similarly to 9-THC. In mice, it results in catalepsy, analgesia, a drop in body temperature, and an overall decrease in activity. There isn’t a scientific predictor of human psychoactivity comparable to that of 9-THC when these four effects are taken into account. Given JWH-018‘s performance in each of the four tests, it is probable that users may encounter psychoactive effects akin to those of THC. In rat drug discrimination trials, JWH-018 produced subjective reactions similar to those of 9-THC and generalized to 9-THC. JWH-018 may have effects similar to those of 9-THC in vivo since it binds to the brain cannabinoid receptor CB1 more firmly than 9-THC and demonstrates agonist characteristics in functional testing.

JWH 018 powder is available via an online vendor situated in the USA. We provide the “Spice” herbal blend in several different forms. Because of the intoxicating effects of its synthetic cannabinoid, which are similar to those of 9-THC in cannabis, the majority of users Use is prohibited. Despite being far more potent than similar cannabis dosages, jwh 018 is also highly challenging to detect using conventional 9-THC testing methods. In July 2009, JWH-018 was listed as a drug and compound of concern by the US Drug Enforcement Agency (DEA). In addition to reports of Spice seizures in Florida and Ohio, states including as Alabama, Arkansas, and Florida have passed legislation that forbids the sale or possession of JWH-018 powder. LegitGrams